Structural variability in M2+ 2-hydroxyphosphonoacetate moderate proton conductors
نویسندگان
چکیده
منابع مشابه
Influenza M2 proton channels.
M2 of the influenza virus is an intriguing transmembrane protein that forms a minuscule proton channel in the viral envelope. Its recognized function is to equilibrate pH across the viral membrane during cell entry and across the trans-Golgi membrane of infected cells during viral maturation. It is vital for viral replication and it is a target for the anti-influenza drugs, amantadine and riman...
متن کاملPretransition Phenomena in Fast-Proton Conductors
The proton transfer along hydrogen-bonded channels has been recognized to be responsible for the charge conduction in many organic and biological systems [1–3]. Proton conducting solids are also of interest because of their potential use in fuel cells [4, 5]. Current interest to fast-proton conductors needs their synthesis, parameterization, and especially understanding of charge transport mech...
متن کاملReview of proton conductors for hydrogen separation
There is a global push to develop a range of hydrogen technologies for timely adoption of the hydrogen economy. This is critical in view of the depleting oil reserves and looming transport fuel shortage, global warming, and increasing pollution. Molecular hydrogen (H2) can be generated by a number of renewable and fossil-fuel-based resources. However, given the high cost of H2 generation by ren...
متن کاملConformational heterogeneity of the M2 proton channel and a structural model for channel activation.
The M2 protein of influenza virus A is a proton-selective ion channel activated by pH. Structure determination by solid-state and solution NMR and X-ray crystallography has contributed significantly to our understanding, but channel activation may involve conformations not captured by these studies. Indeed, solid-state NMR data demonstrate that the M2 protein possesses significant conformationa...
متن کاملStructural basis for proton conduction and inhibition by the influenza M2 protein.
The influenza M2 protein forms an acid-activated and drug-sensitive proton channel in the virus envelope that is important for the virus lifecycle. The functional properties and high-resolution structures of this proton channel have been extensively studied to understand the mechanisms of proton conduction and drug inhibition. We review biochemical and electrophysiological studies of M2 and dis...
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ژورنال
عنوان ژورنال: Pure and Applied Chemistry
سال: 2017
ISSN: 1365-3075,0033-4545
DOI: 10.1515/pac-2016-1003